Votrient 400mg Tablet

1. Product Introduction

Votrient 400mg Tablet is an oral anti-cancer medication used in the treatment of certain advanced-stage cancers. It contains Pazopanib, which belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs). These are targeted cancer therapies that interfere with specific enzymes (tyrosine kinases) responsible for the growth and spread of cancer cells.

Pazopanib works by blocking the formation of new blood vessels (angiogenesis) that supply nutrients and oxygen to tumors, thereby slowing or stopping their growth. Votrient is commonly prescribed for adult patients who are dealing with advanced renal cell carcinoma (kidney cancer) or soft tissue sarcoma that cannot be treated with surgery or has spread to other parts of the body.

This medication should always be taken under the guidance and supervision of a qualified oncologist. Regular monitoring and blood tests are essential during the treatment period.

2. Uses of Votrient 400mg Tablet

Votrient is used in the treatment of:

• Advanced Renal Cell Carcinoma (RCC): A type of kidney cancer that has spread beyond the kidney.

• Advanced Soft Tissue Sarcoma (STS): Includes a wide range of cancers that originate in the soft tissues like muscles, fat, and connective tissue, especially when previous chemotherapy has failed.

• Off-label Uses (under specialist supervision): May be used in other rare cancers where angiogenesis inhibition is beneficial.

It is usually given as a once-daily oral dose, with or without food (though taking it on an empty stomach is often advised for better absorption).

3. Benefits of Votrient 400mg Tablet

✅ Targeted Therapy
Unlike traditional chemotherapy, Votrient specifically targets cancer cell enzymes and blood vessel formation mechanisms, which can lead to fewer side effects and greater precision.

✅ Slows Tumor Growth
Pazopanib effectively slows the progression of tumors by blocking vascular endothelial growth factor receptors (VEGFR), thereby cutting off blood supply to cancer cells.

✅ Delays Disease Progression
Votrient has shown to prolong progression-free survival (PFS) in patients with kidney cancer and soft tissue sarcoma, delaying the need for further aggressive treatments.

✅ Oral Convenience
Being an oral medication, it offers ease of use and better patient compliance compared to intravenous chemotherapy.

✅ Alternative for Non-Operable Tumors
For cancers that are not surgically removable, Votrient offers a non-invasive treatment option that can control the disease and improve quality of life.

4. Side Effects

While Votrient is generally well-tolerated, it may cause certain side effects. The severity and type of side effects vary among individuals.

Common Side Effects:

• Diarrhea

• High blood pressure (hypertension)

• Nausea and vomiting

• Fatigue or weakness

• Loss of appetite

• Weight loss

• Hair color changes

• Abnormal liver function tests

Serious Side Effects (require immediate medical attention):

• Liver toxicity (indicated by yellowing of skin or eyes, dark urine)

• Heart rhythm problems (irregular heartbeat, dizziness, fainting)

• Severe bleeding (nosebleeds, blood in urine or stool)

• Thromboembolic events (blood clots)

• Gastrointestinal perforation (rare but life-threatening)

Important Note: Regular liver function tests and blood pressure monitoring are essential during treatment. Inform your doctor about any pre-existing heart, liver, or bleeding conditions before starting Votrient.

5. Frequently Asked Questions (FAQ)

Q1. How does Votrient 400mg Tablet work?
A: Votrient works by inhibiting tyrosine kinases involved in tumor growth and angiogenesis (formation of new blood vessels). This starves the tumor of nutrients and slows its growth.

Q2. Can Votrient cure cancer?
A: No, Votrient is not a cure, but it can significantly slow down the progression of cancer, manage symptoms, and improve survival in patients with advanced-stage renal cell carcinoma or soft tissue sarcoma.

Q3. How should I take Votrient tablets?
A: Take one tablet (400mg) once daily, on an empty stomach (at least 1 hour before or 2 hours after a meal). Take it at the same time every day unless directed otherwise by your oncologist.

Q4. What should I do if I miss a dose?
A: If you miss a dose, skip it and take the next dose at the regular time. Do not double the dose to make up for a missed one.

Q5. Can I stop taking Votrient if I feel better?
A: No. Continue the treatment as prescribed. Stopping Votrient prematurely can cause the cancer to progress. Only stop when advised by your doctor.