Alburel 20% Injection 100ml

1. Product Introduction

Alburel 20% Injection 100ml is a sterile, highly purified Human Albumin solution used for intravenous administration. Human Albumin is a naturally occurring protein found in blood plasma. This injectable form is derived from healthy human donor plasma and is used to restore and maintain blood volume and pressure in critically ill or hypoalbuminemic patients.

Alburel 20% is considered a plasma volume expander, commonly used in intensive care units, emergency situations, and post-surgical care. It is a high-concentration (20%) formulation, ideal for patients needing rapid albumin replacement in a smaller fluid volume, such as those with fluid restrictions or severe low albumin levels.

This injection must be administered under the supervision of a healthcare professional in a hospital or clinical setting. It plays a vital role in managing various life-threatening conditions by helping maintain oncotic pressure and preventing fluid from leaking into surrounding tissues.

2. Uses of This Medicine

Alburel 20% Injection is used in several clinical scenarios, including:

• Hypoalbuminemia (Low Albumin Levels):
  Used when the body’s natural albumin levels fall due to liver disease, burns, kidney problems, or malnutrition.

• Shock Due to Blood or Plasma Loss:
  Helps restore blood volume in patients suffering from shock caused by trauma, burns, or surgery.

• Liver Cirrhosis and Ascites:
  In patients with cirrhosis, Alburel is used to manage fluid build-up (ascites) and maintain albumin levels during paracentesis (fluid removal).

• Nephrotic Syndrome:
  Used when protein loss from the kidneys causes low albumin levels and edema (swelling).

• Cardiopulmonary Bypass Surgery:
  Assists in fluid management during open-heart surgeries.

• Acute Respiratory Distress Syndrome (ARDS):
  Helps improve fluid balance and oxygen delivery in critically ill patients.

• Burn Injuries and Severe Trauma:
  Aids in fluid resuscitation in burn patients who have lost plasma through damaged skin.

3. Benefits of This Medicine

• Rapid Restoration of Blood Volume:
  Alburel 20% quickly increases plasma volume, especially in patients with hypovolemia or blood loss.

• Improves Oncotic Pressure:
  Albumin plays a key role in maintaining oncotic (colloid osmotic) pressure, preventing fluid leakage into tissues and reducing edema.

• Smaller Volume Required:
  Due to its 20% concentration, a smaller volume of Alburel is needed to achieve the desired plasma-expanding effect compared to 5% solutions. This is ideal for patients with fluid restrictions.

• Essential in Critical Care:
  It supports hemodynamic stability in critically ill patients and is an essential part of intensive care treatment protocols.

• Supports Kidney and Liver Function:
  In patients with conditions like nephrotic syndrome or liver cirrhosis, Alburel helps in symptom relief and stabilization.

• Biocompatible and Safe:
  Since Alburel is made from human plasma, it is well tolerated and closely mimics the natural albumin in the body.

4. Side Effects

While Alburel 20% Injection is generally safe when administered correctly, some patients may experience side effects.

Common Side Effects:

• Mild fever or chills

• Headache

• Flushing

• Nausea or vomiting

• Increased heart rate

• Temporary increase in blood pressure

Serious Side Effects:

• Allergic Reactions:
  Though rare, some people may experience itching, rash, chest tightness, shortness of breath, or anaphylactic shock. Immediate medical attention is required.

• Fluid Overload:
  Overdose or too rapid infusion may lead to fluid overload, resulting in pulmonary edema or heart failure, especially in elderly or cardiac-compromised patients.

• Hypervolemia and Hemodilution:
  Excessive administration may dilute the blood and cause electrolyte imbalance or strain on the circulatory system.

• Thrombosis:
  Rarely, clot formation can occur, especially in patients predisposed to thrombosis.

Precautions:

• Should be administered under supervision only.

• Monitor vital signs and fluid balance during infusion.

• Patients with heart, kidney, or lung diseases should be closely observed.

• Avoid mixing Alburel with other IV fluids unless advised by a doctor.

5. Frequently Asked Questions (FAQ)

Q1. What is Alburel 20% Injection used for?
Alburel 20% is used to treat low albumin levels in the blood due to liver disease, kidney disease, burns, surgeries, or trauma. It is also used to maintain blood volume during shock or fluid loss.

Q2. How is Alburel 20% administered?
It is given through an intravenous (IV) infusion by a healthcare professional. The dose and rate depend on the patient’s condition, age, weight, and clinical needs.

Q3. Is Alburel 20% safe during pregnancy?
There is limited data on its use in pregnancy. It should only be used if the potential benefit outweighs the risk and only under medical supervision.

Q4. Can Alburel cause allergic reactions?
Yes, although rare, some patients may experience allergic or anaphylactic reactions. Always inform your doctor about any history of allergies before receiving this injection.

Q5. How does Alburel 20% differ from Alburel 5%?
Alburel 20% is a more concentrated solution, which means less volume is needed to deliver the same amount of albumin as compared to Alburel 5%. It is preferred in patients who require volume expansion but cannot tolerate large fluid volumes.