Dasatib 100mg Tablet

1. Product Introduction

Dasatib 100mg Tablet contains Dasatinib, a potent anti-cancer medication used in the treatment of certain types of leukemia, specifically Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL) that are Philadelphia chromosome-positive. Dasatinib belongs to the class of medications called tyrosine kinase inhibitors (TKIs). These drugs work by blocking the activity of an abnormal protein that signals cancer cells to multiply, thereby slowing or stopping the spread of cancer.

Dasatib is usually prescribed when patients do not respond adequately to other treatments like imatinib or if they develop resistance. The drug is taken orally and is usually prescribed as part of a long-term treatment plan under strict supervision by an oncologist.

2. Uses of This Medicine

Dasatib 100mg Tablet is primarily used for the treatment of:

• Chronic Myeloid Leukemia (CML):
  Used in adults with chronic, accelerated, or blast phase CML, especially when other treatments fail or are not tolerated.

• Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL):
  Approved for adults with newly diagnosed or resistant/refractory Ph+ ALL.

• Second-Line Therapy:
  Effective in patients who are intolerant or resistant to first-line tyrosine kinase inhibitors such as imatinib.

Dasatib is not a cure but significantly improves survival and disease control in patients with leukemia.

3. Benefits of This Medicine

Dasatib 100mg Tablet provides several therapeutic benefits in the management of leukemia, especially in difficult-to-treat or resistant cases.

Key Benefits:

• Targeted Therapy:
  Dasatinib specifically targets and blocks the BCR-ABL protein, which is responsible for uncontrolled cell division in leukemia. This makes it more effective with fewer side effects compared to traditional chemotherapy.

• Slows Disease Progression:
  In chronic phases of leukemia, it helps maintain remission and delays the progression to more aggressive stages.

• Useful in Resistant Cases:
  Offers a second-line treatment option when other drugs, like imatinib, fail due to resistance or side effects.

• Oral Administration:
  Easy to take at home, reducing the need for hospital visits compared to injectable chemotherapy agents.

• Improves Overall Survival:
  Clinical studies have shown that patients taking Dasatinib have improved response rates and longer overall survival.

• Faster Response:
  Compared to some other TKIs, Dasatinib can produce a quicker molecular and cytogenetic response in patients.

4. Side Effects

While Dasatib 100mg is highly effective, it may cause side effects in some individuals. Most side effects are manageable and can be addressed with supportive care or dose adjustments.

Common Side Effects:

• Fatigue

• Headache

• Nausea or vomiting

• Diarrhea

• Loss of appetite

• Skin rash

• Muscle pain or joint pain

• Fluid retention (swelling around eyes, ankles)

Serious Side Effects (Less Common):

• Pleural effusion (fluid around the lungs)

• Myelosuppression (low blood cell counts)

• Infections due to reduced immunity

• QT prolongation (irregular heart rhythm)

• Liver function abnormalities

• Bleeding or bruising easily

Important: Inform your doctor immediately if you experience chest pain, difficulty breathing, signs of infection (fever, chills), or unusual bleeding.

Patients on Dasatinib should undergo regular blood tests to monitor blood counts, liver function, and heart health.

5. Frequently Asked Questions (FAQ)

Q1. What is Dasatib 100mg Tablet used for?
It is used to treat Philadelphia chromosome-positive Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (Ph+ ALL), especially in patients who are resistant or intolerant to previous therapy.

Q2. How does Dasatinib work?
Dasatinib blocks the abnormal BCR-ABL tyrosine kinase protein that causes leukemia cells to grow uncontrollably. By inhibiting this enzyme, the drug helps slow or stop cancer cell proliferation.

Q3. How should I take Dasatib 100mg Tablet?
Take it exactly as prescribed by your doctor. It is usually taken once daily with or without food. Swallow the tablet whole with water; do not crush or break it.

Q4. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it is near the time for your next dose, skip the missed dose. Do not double the dose to catch up.

Q5. Can Dasatinib be taken during pregnancy?
No. Dasatinib can cause serious harm to an unborn baby. Effective contraception should be used during treatment and for a period afterward. It is not recommended during pregnancy or breastfeeding.