FOIRI 100 Injection

1. Product Introduction

FOIRI 100 Injection is an anti-cancer medication that contains Irinotecan as its active ingredient. Irinotecan belongs to a class of drugs known as topoisomerase I inhibitors. It is used primarily in the treatment of colorectal cancer, especially in advanced or metastatic cases.

FOIRI 100 is a chemotherapy drug that works by interfering with the DNA replication process in cancer cells, ultimately leading to cell death. It is typically given as part of a combination chemotherapy regimen, such as FOLFIRI (Folinic acid, Fluorouracil, and Irinotecan), under strict medical supervision in a hospital or oncology clinic.

This injection is administered intravenously by trained healthcare professionals. FOIRI 100 is a crucial component in the treatment protocols for patients who may not have responded well to previous cancer therapies or for those in later stages of the disease.

2. Uses of This Medicine

FOIRI 100 Injection is used primarily for:

• Metastatic Colorectal Cancer (mCRC):
  It is used either alone or in combination with other chemotherapeutic agents to treat cancers that have spread beyond the colon or rectum.

• Second-line Treatment:
  FOIRI 100 is often administered to patients whose colorectal cancer has progressed after initial treatment with fluorouracil-based therapies.

• Off-label Use (in some cases):
  It may be used in the management of other solid tumors such as gastric or pancreatic cancers based on a physician’s assessment and clinical trial data.

3. Benefits of This Medicine

• Inhibits Cancer Cell Growth:
  Irinotecan directly targets cancer cells by inhibiting topoisomerase I, an enzyme essential for DNA replication. This helps slow down or stop the growth of tumors.

• Prolongs Survival in Advanced Cancer:
  When used in combination with other drugs, FOIRI 100 has been shown to increase overall survival and progression-free survival in colorectal cancer patients.

• Effective After First-Line Therapy Failure:
  It provides a treatment option for patients who have not responded to first-line chemotherapy, making it valuable in continuing cancer control.

• Flexible in Combination Therapy:
  FOIRI 100 is widely used in well-known regimens like FOLFIRI, which have been proven effective and are globally accepted in oncology treatment plans.

• Improves Quality of Life:
  Although not curative in advanced cancer, FOIRI 100 can help reduce symptoms, shrink tumors, and enhance quality of life in patients undergoing palliative care.

4. Side Effects

Like all chemotherapy agents, FOIRI 100 Injection may cause side effects. Some side effects are common and manageable, while others may require immediate medical attention.

Common Side Effects:

• Nausea and vomiting

• Diarrhea (early-onset and delayed-onset)

• Fatigue or weakness

• Loss of appetite

• Hair thinning or loss

• Abdominal cramps

Serious Side Effects:

• Severe diarrhea leading to dehydration

• Neutropenia (low white blood cell count), increasing the risk of infection

• Fever or chills (sign of infection)

• Breathing difficulties

• Mouth ulcers

• Liver enzyme abnormalities

Precautions:

• Patients should stay well-hydrated and report any diarrhea, fever, or signs of infection to their doctor immediately.

• Routine blood tests are needed before each treatment to monitor liver function and blood counts.

• This medication should be avoided during pregnancy and breastfeeding.

Drug Interactions:

• Avoid using with drugs that may affect liver enzymes or gastrointestinal motility unless prescribed.

• Inform your doctor about all the medications and supplements you are using.

5. Frequently Asked Questions (FAQ)

Q1. What is FOIRI 100 Injection used for?
A: It is mainly used to treat metastatic colorectal cancer, especially in patients who have not responded to other chemotherapy drugs.

Q2. How is FOIRI 100 administered?
A: It is given as an intravenous infusion in a hospital setting under the supervision of an oncologist or trained medical staff.

Q3. How often is the treatment given?
A: The frequency depends on your treatment protocol, usually once every 1 to 2 weeks, as determined by your oncologist. It’s often part of a chemotherapy cycle.

Q4. Can FOIRI 100 cure cancer?
A: While FOIRI 100 may not cure advanced cancer, it can prolong survival, shrink tumors, and significantly improve symptoms and quality of life.

Q5. What should I do if I develop severe diarrhea after the injection?
A: Inform your doctor immediately. You may be given anti-diarrheal medications like loperamide and IV fluids if necessary.