Hemazide O 300mg Tablet

1. Product Introduction

Hemazide O 300mg Tablet is an oral anticancer medicine containing Azacitidine (300mg), a hypomethylating agent used in the treatment of various blood and bone marrow cancers, particularly myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). It belongs to a class of drugs that work by altering the way DNA is expressed in abnormal cells, thereby slowing down or stopping their growth.

Azacitidine was traditionally given via injection, but with advanced formulations like Hemazide O, it is now available in oral tablet form, making treatment more convenient, especially for long-term use. The medicine works at the cellular level by inhibiting abnormal DNA methylation, which helps reactivate tumor suppressor genes and restores the normal function of blood-forming cells in the bone marrow.

This drug plays a critical role in preventing disease progression, especially in elderly patients who may not tolerate aggressive chemotherapy. It is generally used under strict medical supervision, with close monitoring of blood counts and organ functions.

2. Uses of This Medicine

Hemazide O 300mg Tablet is used in the treatment of:

• Myelodysplastic Syndromes (MDS): A group of disorders where the bone marrow produces underdeveloped or faulty blood cells.

• Acute Myeloid Leukemia (AML): A type of aggressive blood cancer, particularly in patients who are not suitable for intensive chemotherapy.

• Chronic Myelomonocytic Leukemia (CMML): A type of leukemia affecting both myelodysplastic and myeloproliferative components.

• Maintenance Therapy: For patients in remission or following chemotherapy to prevent relapse and progression of disease.

3. Benefits of This Medicine

Hemazide O 300mg Tablet provides several advantages in managing complex blood disorders:

• Convenient Oral Administration: Eliminates the need for hospital-based injections, enabling patients to take the treatment at home.

• Effective Disease Control: Helps in slowing or stopping the progression of MDS and AML by targeting abnormal cells.

• Improves Blood Cell Counts: Aids in restoring normal blood production (red cells, white cells, and platelets), reducing symptoms like anemia and infections.

• Reduces Transfusion Needs: Many patients experience a significant reduction in the need for blood transfusions.

• Prolongs Survival: Clinical studies have shown that Azacitidine improves overall survival in MDS and AML patients, particularly in the elderly.

• Better Tolerability: Offers a less toxic alternative to conventional chemotherapy, especially for those who cannot tolerate intensive regimens.

• Maintenance and Remission Support: Plays a valuable role in maintaining remission and preventing relapse.

4. Side Effects

Like most cancer therapies, Hemazide O 300mg Tablet may cause side effects, though not everyone experiences them. The severity and frequency of these effects can vary depending on the patient’s overall health and dosage.

Common Side Effects:

• Nausea and vomiting

• Fatigue or general weakness

• Diarrhea or constipation

• Loss of appetite

• Low blood counts (anemia, leukopenia, thrombocytopenia)

• Headache or dizziness

Serious Side Effects:

• Infections due to low white blood cell count (fever, chills, sore throat)

• Unusual bleeding or bruising (due to low platelet count)

• Liver or kidney dysfunction

• Breathing difficulties

• Severe allergic reactions (rash, swelling, itching)

Precautions:

• Regular blood tests are essential to monitor blood cell counts and organ function.

• Use caution in patients with liver or kidney impairment.

• Avoid pregnancy during treatment, as Azacitidine may harm the unborn baby.

• Patients should maintain good hygiene and avoid contact with sick individuals to prevent infections.

• Inform the doctor of all medications being used to prevent harmful drug interactions.

5. Frequently Asked Questions (FAQ)

Q1. What is Hemazide O 300mg Tablet used for?
A: It is primarily used for treating Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML), and Chronic Myelomonocytic Leukemia (CMML).

Q2. How does Azacitidine work in cancer treatment?
A: Azacitidine works by altering DNA methylation, which reactivates tumor suppressor genes and slows the growth of abnormal cells in the bone marrow.

Q3. How is Hemazide O different from injectable Azacitidine?
A: Both contain the same active ingredient, but Hemazide O is in tablet form, offering the convenience of oral intake and reducing the need for frequent hospital visits.

Q4. Can Hemazide O be used in all age groups?
A: It is mostly prescribed to adult patients, especially elderly individuals with bone marrow disorders. It is not recommended for pediatric use unless explicitly advised by a specialist.

Q5. How long does Hemazide O treatment last?
A: Treatment duration depends on the disease response and tolerance. It is usually given in 28-day cycles, and multiple cycles may be needed for effectiveness.