Imatib 400 Tablet

1. Product Introduction

Imatib 400 Tablet is an anti-cancer medicine used primarily in the treatment of specific types of blood and gastrointestinal cancers. The active ingredient, Imatinib Mesylate, is a tyrosine kinase inhibitor (TKI) that targets and blocks the abnormal proteins (tyrosine kinases) responsible for the uncontrolled growth of cancer cells.

It is widely used as a first-line treatment for Chronic Myeloid Leukemia (CML) and Acute Lymphoblastic Leukemia (ALL), as well as for Gastrointestinal Stromal Tumors (GIST). Imatib works at the molecular level by preventing cancer cells from multiplying and helps in controlling the progression of the disease.

Imatib 400 is available in oral tablet form, making it convenient for outpatient therapy. This targeted cancer therapy has transformed the prognosis of leukemia and GIST patients and continues to be a crucial part of oncological treatment protocols.

2. Uses of Imatib 400 Tablet

Imatib 400 Tablet is indicated for the treatment of the following medical conditions:

• Chronic Myeloid Leukemia (CML): Especially Philadelphia chromosome-positive (Ph+) CML in chronic, accelerated, or blast crisis phase.

• Acute Lymphoblastic Leukemia (ALL): Especially in patients with Ph+ ALL.

• Gastrointestinal Stromal Tumors (GIST): A rare type of cancer affecting the digestive tract.

• Myelodysplastic/Myeloproliferative Diseases (MDS/MPD): Especially associated with PDGFR gene rearrangements.

• Systemic Mastocytosis (SM): A rare condition involving abnormal mast cells.

• Hypereosinophilic Syndrome (HES) and/or Chronic Eosinophilic Leukemia (CEL)

• Dermatofibrosarcoma Protuberans (DFSP): A rare skin tumor.

3. Benefits of Imatib 400 Tablet

• Targeted Therapy: Imatib works by selectively targeting the abnormal tyrosine kinase proteins in cancer cells without significantly harming normal cells.

• Improved Survival Rates: Proven to significantly improve life expectancy in patients with CML and GIST.

• Slows Disease Progression: In many cases, it helps bring cancer into remission or slow its advancement.

• Oral Convenience: Taken as a tablet, it allows treatment outside hospital settings, enhancing patient convenience.

• Well-Tolerated: For most patients, it offers an effective treatment option with manageable side effects compared to traditional chemotherapy.

• First-Line Therapy for CML and GIST: Recognized globally as a standard first-line treatment for several cancers.

• Reduced Need for Chemotherapy: Often used instead of or in combination with chemotherapy, lowering toxicity.

4. Side Effects

Like all medications, Imatib 400 Tablet may cause side effects. However, not all patients will experience them, and many side effects can be managed with supportive care or dose adjustment.

Common Side Effects:

• Nausea and vomiting

• Muscle cramps or joint pain

• Swelling around the eyes or ankles (fluid retention)

• Diarrhea

• Fatigue or weakness

• Rash or skin irritation

• Abdominal pain

Less Common Side Effects:

• Headache or dizziness

• Weight gain or weight loss

• Increased risk of infection due to low white blood cells

• Decreased platelet count (leading to easy bruising or bleeding)

• Elevated liver enzymes

Serious Side Effects (Rare but Important):

• Severe allergic reactions

• Liver damage or hepatitis

• Heart failure in patients with pre-existing conditions

• Gastrointestinal bleeding

Precautions:

• Regular monitoring of blood counts, liver function, and kidney function is required.

• Use with caution in patients with cardiac, renal, or liver disorders.

• Avoid grapefruit juice and alcohol during treatment.

• Not recommended during pregnancy or breastfeeding unless specifically prescribed.

5. Frequently Asked Questions (FAQ)

Q1. What is Imatib 400 used for?
A: It is used to treat specific cancers like Chronic Myeloid Leukemia (CML), Acute Lymphoblastic Leukemia (ALL), and Gastrointestinal Stromal Tumors (GIST).

Q2. How does Imatib 400 work?
A: It blocks abnormal proteins in cancer cells called tyrosine kinases, thereby stopping the cancer cells from growing and dividing.

Q3. How should I take Imatib 400 Tablet?
A: Take it with a full glass of water after a meal, usually once daily, or as prescribed by your doctor. Do not crush or chew the tablet.

Q4. Can Imatib cure cancer?
A: While it may not cure cancer, it is very effective in controlling the disease, especially in CML, where long-term remissions are possible.

Q5. What should I do if I miss a dose?
A: Take the missed dose as soon as you remember. If it’s close to the time of the next dose, skip the missed dose. Do not take a double dose.