Lenvenib 4mg Capsule

1. Product Introduction

Lenvenib 4mg Capsule is an anti-cancer medication that contains Lenvatinib, a powerful tyrosine kinase inhibitor (TKI). It is primarily used for treating various types of cancers, especially thyroid cancer, renal cell carcinoma (kidney cancer), and hepatocellular carcinoma (liver cancer). Lenvatinib works by inhibiting the activity of specific proteins (kinases) that are responsible for cancer cell growth and the development of blood vessels that supply nutrients to tumors.

By cutting off this blood supply and blocking cancer cell multiplication, Lenvenib slows down or stops the growth and spread of cancer. It is usually prescribed when surgery or radiation therapy is not effective or possible. Lenvenib is often used alone or in combination with other anti-cancer medications depending on the type and stage of cancer.

This medication should always be taken under the supervision of a qualified oncologist.

2. Uses of This Medicine

Lenvenib 4mg Capsule is used in the treatment of the following cancers:

• Differentiated Thyroid Cancer (DTC): Especially when the disease is radioactive iodine-refractory, meaning it no longer responds to standard radioactive iodine therapy.

• Renal Cell Carcinoma (RCC): A common type of kidney cancer, especially in advanced stages, and often used in combination with other drugs like everolimus or pembrolizumab.

• Hepatocellular Carcinoma (HCC): The most common form of liver cancer, especially in patients who cannot undergo surgical or locoregional therapy.

• Endometrial Cancer: In certain advanced or recurrent cases, especially in combination with immunotherapy agents.

Your doctor may also prescribe it for other types of solid tumors as part of experimental or off-label use, based on clinical guidelines.

3. Benefits of This Medicine

• Slows Tumor Growth: Lenvenib targets multiple enzymes (receptors) responsible for tumor growth, cutting off the blood supply to the cancer and helping shrink the tumor size.

• Oral Administration: Being a capsule, it is convenient to take at home, avoiding the need for frequent hospital visits for IV chemotherapy.

• Effective in Radioiodine-Refractory Thyroid Cancer: Lenvenib has become a crucial treatment for thyroid cancer patients who no longer respond to standard treatments.

• Combination Therapy Option: Can be combined with other therapies (e.g., pembrolizumab or everolimus) to increase efficacy in advanced cancers.

• Improved Progression-Free Survival: Clinical trials have shown that Lenvenib significantly prolongs the time during which the cancer does not get worse.

• Multi-target Action: Targets not just cancer cells but also the supporting network (blood vessels and growth factors), making it harder for tumors to survive and spread.

4. Side Effects

Like most cancer therapies, Lenvenib 4mg Capsule may cause side effects. Some side effects are manageable, while others may require dose adjustment or temporary discontinuation.

Common Side Effects:

• High blood pressure (hypertension)

• Fatigue or weakness

• Diarrhea

• Weight loss

• Nausea and vomiting

• Loss of appetite

• Mouth sores

• Swelling in the hands or feet

• Headache

• Hoarseness

Serious Side Effects (Seek medical help):

• Liver problems (jaundice, dark urine, upper abdominal pain)

• Heart issues (irregular heartbeat, chest pain)

• Kidney dysfunction

• Severe bleeding or blood clots

• Gastrointestinal perforation or fistulas

• Severe allergic reactions

• Protein in urine (proteinuria)

Precautions:

• Monitor blood pressure regularly.

• Liver and kidney function tests may be required during treatment.

• Not recommended during pregnancy or breastfeeding.

• Avoid grapefruit juice as it may affect drug levels.

Always consult your oncologist about side effect management and report any severe or unusual symptoms immediately.

5. Frequently Asked Questions (FAQ)

Q1. What is Lenvenib 4mg Capsule used for?

A: It is used to treat several types of cancer including thyroid, kidney, and liver cancer. It works by slowing tumor growth and reducing blood flow to the tumor.

Q2. How should I take Lenvenib?

A: Take it orally once a day as directed by your doctor, preferably at the same time each day. It can be taken with or without food. Swallow the capsule whole; do not crush or chew it.

Q3. Can Lenvenib be taken during pregnancy?

A: No, Lenvenib is not safe during pregnancy as it may harm the fetus. Women of childbearing age should use effective contraception during and after the treatment as advised by their doctor.

Q4. Can I stop taking Lenvenib if I feel better?

A: No, do not stop taking the medicine without your doctor’s advice. Even if symptoms improve, the cancer may still be active. Always follow your oncologist’s guidance.

Q5. What should I do if I miss a dose?

A: If you miss a dose and remember it within 12 hours, take it as soon as possible. If more than 12 hours have passed, skip the missed dose and take the next dose at the regular time. Do not double the dose.

Q6. Are there dietary restrictions while on Lenvenib?