Midostar 25mg Capsule

Product Introduction

Midostar 25mg Capsule is an anti-cancer medication that contains Midostaurin (25mg) as its active ingredient. It belongs to a class of drugs known as multi-targeted kinase inhibitors, specifically designed to interfere with abnormal enzymes (kinases) that promote the growth and spread of cancer cells. Midostar is particularly effective in targeting mutations such as FLT3 and KIT, commonly found in certain forms of leukemia and rare blood disorders.

Midostar is primarily prescribed for patients with acute myeloid leukemia (AML) that tests positive for the FLT3 mutation, in combination with standard chemotherapy. Additionally, it is used in the treatment of advanced systemic mastocytosis (ASM) and related conditions such as mast cell leukemia (MCL) and systemic mastocytosis with associated hematological neoplasm (SM-AHN).

Available in convenient capsule form, Midostar is usually taken twice a day with food. Due to the complexity of the conditions it treats, this medication should be used strictly under the supervision of a specialized oncologist or hematologist, and regular follow-ups and lab monitoring are essential.

Uses of this medicine

Midostar 25mg Capsule is used in the treatment of:

• Acute Myeloid Leukemia (AML) with FLT3 mutation (in combination with chemotherapy)

• Aggressive Systemic Mastocytosis (ASM)

• Systemic Mastocytosis with Associated Hematological Neoplasm (SM-AHN)

• Mast Cell Leukemia (MCL)

Benefits of this medicine

1. Targets Specific Genetic Mutations
Midostar is designed to inhibit abnormal proteins caused by gene mutations such as FLT3 and KIT. By directly targeting these mutations, it disrupts the pathways that allow cancerous cells to multiply and survive.

2. Improved Survival in AML
When used in combination with chemotherapy, Midostar significantly improves overall survival rates in patients with FLT3-mutated AML. It helps in reducing relapse rates and enhances long-term treatment outcomes.

3. Effective in Rare Blood Cancers
For patients diagnosed with systemic mastocytosis and related disorders, Midostar provides one of the few effective treatment options available, reducing symptoms and disease burden significantly.

4. Oral Convenience
Midostar comes in capsule form, making it easier for patients to take at home. This reduces the need for frequent hospital visits, enhancing convenience and adherence to therapy.

5. Symptom Relief
By targeting mast cell proliferation in systemic mastocytosis, Midostar helps alleviate symptoms such as bone pain, gastrointestinal discomfort, skin rashes, and organ swelling.

6. Personalized Treatment Option
The therapy is tailored for patients based on genetic testing, making it a personalized medicine option that offers more precise and effective treatment.

Side Effects

Like all cancer medications, Midostar 25mg Capsule may cause side effects. Most side effects are manageable, especially when detected early. It’s important for patients to be regularly monitored during the course of treatment.

Common Side Effects:

• Nausea and vomiting

• Diarrhea

• Fatigue or weakness

• Loss of appetite

• Fever

• Rash

• Headache

• Cough or respiratory infections

Serious Side Effects (require immediate medical attention):

• Abnormal liver function

• Bleeding or bruising easily

• Changes in heart rhythm (QT prolongation)

• Shortness of breath or chest pain

• Swelling of face or limbs

• Visual disturbances

• Severe allergic reactions (swelling, rash, trouble breathing)

Monitoring Required:

• Complete blood count (CBC)

• Liver function tests (LFTs)

• Electrocardiogram (ECG)

• FLT3 mutation analysis (before treatment)

Frequently Asked Questions (FAQ)

1. What is Midostar 25mg Capsule used for?
Midostar is used to treat FLT3-mutated acute myeloid leukemia (AML) in combination with chemotherapy, and rare forms of blood cancers such as systemic mastocytosis, SM-AHN, and mast cell leukemia.

2. How should I take Midostar?
Midostar should be taken orally, twice daily (every 12 hours), with food. Swallow the capsule whole with water. Do not crush or chew the capsules.

3. Can I take Midostar during pregnancy?
No, Midostar is not safe during pregnancy as it may harm the unborn baby. Effective contraception must be used during treatment and for at least 4 months after the last dose.

4. What should I do if I miss a dose?
If less than 6 hours have passed since your missed dose, take it as soon as you remember. If more than 6 hours have passed, skip the missed dose and resume your normal schedule. Do not take a double dose to make up for the missed one.

5. Are there any foods or drinks I should avoid while taking Midostar?
Avoid grapefruit or grapefruit juice, as it can interfere with the metabolism of the drug and increase the risk of side effects.

References