Pamorelin LA 11.25mg Injection

1. Product Introduction

Pamorelin LA 11.25mg Injection is a long-acting injectable formulation containing Triptorelin, a synthetic hormone analogue of gonadotropin-releasing hormone (GnRH). It is primarily used for hormone-sensitive conditions such as prostate cancer, endometriosis, and uterine fibroids. By acting on the pituitary gland, Triptorelin significantly reduces the levels of testosterone in men and estrogen in women, both of which play a key role in the progression of certain hormone-dependent diseases.

This injection is designed for intramuscular administration once every three months (usually every 12 weeks), offering a convenient dosing schedule for long-term treatment. It is administered by a healthcare professional and requires monitoring of hormone levels and clinical response over time.

Pamorelin LA 11.25mg provides a sustained-release effect, allowing the medication to gradually release Triptorelin into the body to maintain effective hormone suppression throughout the dosing period.

2. Uses of Pamorelin LA 11.25mg Injection

Pamorelin LA 11.25mg Injection is commonly prescribed for:

• Advanced or Metastatic Prostate Cancer (in men): To reduce testosterone production and slow cancer growth.

• Endometriosis (in women): To reduce estrogen levels and relieve symptoms such as pelvic pain and painful periods.

• Uterine Fibroids (in women): To shrink fibroids and reduce associated symptoms, sometimes used prior to surgery.

• Precocious Puberty (in children): To delay early onset puberty by suppressing the pituitary hormone signals.

This medication is used as part of a comprehensive treatment plan, often in combination with other therapies based on the patient’s diagnosis and medical history.

3. Benefits of Pamorelin LA 11.25mg Injection

• Long-Lasting Hormone Suppression: With one injection every 3 months, Pamorelin provides consistent and effective control of hormone levels, reducing the need for frequent dosing.

• Prostate Cancer Management: It slows the growth and spread of prostate cancer by lowering testosterone levels, which prostate cancer cells rely on for growth.

• Relief from Endometriosis Symptoms: By lowering estrogen levels, Pamorelin significantly reduces pelvic pain, menstrual cramps, and endometrial tissue growth.

• Pre-Surgical Use in Fibroids: It is often used before surgery to reduce the size of uterine fibroids, making surgical removal easier and reducing intraoperative blood loss.

• Convenient Dosing Schedule: The 3-month dosing schedule improves patient compliance and offers greater convenience than daily or monthly alternatives.

• Effective in Pediatric Use: In children with precocious puberty, it helps to delay premature sexual development and allows normal growth and emotional development.

• Well-Studied Safety Profile: Triptorelin is a clinically established treatment with proven safety and efficacy across various hormone-related conditions.

4. Side Effects

Like all medications, Pamorelin LA 11.25mg Injection may cause side effects. Most are temporary and manageable, but some may require medical attention.

Common Side Effects in Men:

• Hot flashes

• Decreased libido (reduced sex drive)

• Erectile dysfunction

• Sweating and fatigue

• Bone thinning (osteoporosis) over long-term use

Common Side Effects in Women:

• Vaginal dryness

• Mood changes or irritability

• Irregular periods or complete menstrual suppression

• Hot flashes and night sweats

Common in Children:

• Injection site pain

• Mild hormonal imbalance effects

• Temporary increase in symptoms (hormonal flare) at the beginning

Serious Side Effects (Rare):

• Allergic reactions (swelling, itching, rash)

• Bone loss or osteoporosis

• Liver function changes

• Cardiovascular symptoms (chest pain, palpitations)

Hormonal Flare Reaction: At the start of treatment, some patients may experience a temporary worsening of symptoms (called a “flare”), which typically subsides after a few days or weeks.

Monitoring Required: Patients on long-term therapy should undergo regular check-ups, including hormone level tests, liver function tests, and bone density scans.

5. Frequently Asked Questions (FAQs)

Q1. How is Pamorelin LA 11.25mg Injection administered?
It is given as an intramuscular injection by a healthcare professional once every 12 weeks (3 months). Do not self-administer.

Q2. How long does it take for the medicine to work?
Hormone levels typically start to reduce within 2–4 weeks of the first injection. Full clinical benefits may take longer, depending on the condition being treated.

Q3. Will I experience a “flare-up” at the beginning of treatment?
Yes, some patients may experience a temporary flare-up of symptoms, such as bone pain or urinary issues in prostate cancer. Your doctor may prescribe additional medications to manage this.

Q4. Is this injection a cure for prostate cancer or endometriosis?
No, Pamorelin is not a cure but a long-term disease management medication that helps control hormone-driven conditions and relieve symptoms.

Q5. Can women become pregnant while on Pamorelin?
Although Pamorelin reduces fertility, it is not a contraceptive. Women of childbearing age should use non-hormonal birth control methods during treatment.