Piciclib 125mg Capsule

1. Product Introduction

Piciclib 125mg Capsule is an oral anti-cancer medication that contains Palbociclib, a cyclin-dependent kinase (CDK) 4/6 inhibitor. It is a type of targeted therapy used in the treatment of hormone receptor-positive (HR+), HER2-negative breast cancer.

Palbociclib works by inhibiting specific proteins (CDK4 and CDK6) that are responsible for cell division and cancer cell growth. By blocking these proteins, Piciclib helps to slow down or stop the proliferation of cancer cells. It is most commonly used in combination with hormone therapies like Letrozole or Fulvestrant in postmenopausal women or men with advanced or metastatic breast cancer.

Piciclib has shown significant benefits in extending progression-free survival in patients, offering a better quality of life and prolonged disease control.

2. Uses of This Medicine

Piciclib 125mg Capsule is primarily prescribed for the treatment of:

• Advanced or Metastatic Breast Cancer:
  For patients with HR-positive, HER2-negative breast cancer that has spread beyond the breast or cannot be removed surgically.

• Combination Therapy:
  Typically used along with:

  • Aromatase inhibitors like Letrozole in postmenopausal women as a first-line treatment.

  • Fulvestrant in women whose disease has progressed following prior endocrine therapy.

• Men with Breast Cancer:
  It can also be prescribed for male patients with hormone-sensitive breast cancer.

Piciclib is not used for HER2-positive breast cancers or triple-negative breast cancers.

3. Benefits of This Medicine

• Targeted Cancer Therapy:
  Palbociclib selectively targets cancer cell division mechanisms without affecting normal cells as aggressively as chemotherapy.

• Improves Progression-Free Survival (PFS):
  In clinical studies, Piciclib combined with hormone therapy has been proven to double the time patients live without disease progression.

• Oral Administration:
  Convenient to use at home in capsule form, avoiding the need for intravenous infusions.

• Synergistic Effect:
  When combined with hormonal treatments, Piciclib enhances anti-cancer efficacy by addressing two key cancer growth pathways simultaneously.

• Better Quality of Life:
  Patients often tolerate Piciclib well, and the side effect profile is generally manageable compared to traditional chemotherapy.

• Effective in Pre- and Post-Menopausal Women:
  It is useful across different patient profiles when used with the appropriate hormonal therapy.

4. Side Effects

Like all medications, Piciclib 125mg Capsule may cause some side effects. Not everyone experiences these, and many are mild or manageable with supportive care.

Common Side Effects:

• Neutropenia (low white blood cell count)

• Fatigue or weakness

• Nausea and vomiting

• Mouth sores (stomatitis)

• Diarrhea

• Hair thinning or hair loss

• Anemia

• Loss of appetite

• Skin rash

Serious Side Effects (Require Immediate Medical Attention):

• Signs of infection (fever, chills, sore throat)

• Severe fatigue or breathlessness

• Easy bruising or bleeding

• Severe allergic reactions (rare)

Note: Regular blood tests are necessary to monitor your white blood cell counts during treatment.

5. Frequently Asked Questions (FAQ)

Q1. What is Piciclib 125mg Capsule used for?
A: It is used to treat hormone receptor-positive, HER2-negative breast cancer that is locally advanced or metastatic. It is given in combination with hormonal therapy.

Q2. How does Piciclib (Palbociclib) work?
A: Palbociclib inhibits CDK4/6 proteins which are crucial for cancer cell division. By stopping these, the medicine slows cancer progression.

Q3. How should I take Piciclib 125mg?
A: Take the capsule orally once daily with food. It is usually taken for 21 consecutive days followed by a 7-day break in a 28-day treatment cycle.

Q4. Can I take this medicine on an empty stomach?
A: No, it is recommended to take Piciclib with food to ensure proper absorption and effectiveness.

Q5. What should I do if I miss a dose?
A: If you miss a dose, skip it and take your next dose at the regular time. Do not take two doses at once.