Rompag 25mg Tablet

1. Product Introduction

Rompag 25mg Tablet is a medication that contains Eltrombopag, a thrombopoietin receptor agonist used to stimulate the production of platelets in the bone marrow. It is primarily prescribed for patients who suffer from low platelet counts, a condition known as thrombocytopenia, which can lead to serious bleeding complications if left untreated.

Eltrombopag works by activating the thrombopoietin receptor, thereby promoting the proliferation and differentiation of megakaryocytes (the cells that produce platelets). Rompag is particularly useful in patients who have not responded adequately to other treatments or in those with chronic conditions that result in persistently low platelet counts.

This medication is a significant advancement in the management of chronic immune thrombocytopenia (ITP) and is also used in specific cases of hepatitis C-related thrombocytopenia and severe aplastic anemia.

2. Uses of This Medicine

Rompag 25mg Tablet is used in the treatment of the following conditions:

• Chronic Immune Thrombocytopenia (ITP): For adults and children who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. ITP is an autoimmune condition where the immune system destroys the body’s platelets.

• Thrombocytopenia in Hepatitis C: For patients with chronic hepatitis C virus (HCV) infection to enable and maintain antiviral therapy by raising platelet counts.

• Severe Aplastic Anemia: In patients who have not responded to previous immunosuppressive therapy. Aplastic anemia is a rare disease where the bone marrow fails to produce enough blood cells, including platelets.

Doctors may also consider off-label use of this drug in other thrombocytopenic conditions under strict supervision.

3. Benefits of This Medicine

• Boosts Platelet Count: Eltrombopag helps to increase platelet production, thereby reducing the risk of bleeding in patients with low platelet levels.

• Enables Continuation of Antiviral Therapy: In hepatitis C patients with thrombocytopenia, it allows uninterrupted antiviral therapy which is crucial for treating the underlying infection.

• Improves Quality of Life: By reducing bleeding episodes and transfusion dependence, it helps patients manage their daily activities with more confidence.

• Non-invasive Option: As an oral tablet, Rompag offers a convenient alternative to injectable treatments like platelet transfusions or IV immunoglobulin therapy.

• Used in Refractory Cases: Rompag can be effective in patients who have not responded to other therapies, providing an option where other treatments have failed.

• Reduces Need for Splenectomy: In chronic ITP, it may delay or eliminate the need for surgical removal of the spleen.

4. Side Effects

Like all medications, Rompag 25mg Tablet may cause side effects. While not everyone experiences them, it’s important to monitor for any adverse reactions and inform your doctor promptly.

Common Side Effects:

• Headache

• Fatigue

• Nausea

• Diarrhea

• Muscle aches

• Upper respiratory tract infections

• Increased liver enzymes (transaminases)

Serious Side Effects:

• Liver toxicity: Eltrombopag can cause liver problems; liver function tests must be monitored regularly.

• Blood clots (thrombosis): Especially if platelet counts rise too quickly.

• Cataracts: In long-term use.

• Bone marrow fibrosis: Rare but serious side effect.

• Rebound thrombocytopenia: Platelet levels may drop suddenly if the medication is stopped abruptly.

Precautions:

• Regular monitoring of platelet counts and liver function is essential during treatment.

• Avoid antacids, dairy products, or supplements containing calcium, magnesium, aluminum, or iron within 2 hours of taking Rompag, as they may reduce its absorption.

• Not recommended during pregnancy or breastfeeding unless advised by the doctor.

5. Frequently Asked Questions (FAQ)

Q1. What is Rompag 25mg Tablet used for?

A: Rompag is used to treat low platelet counts in patients with chronic immune thrombocytopenia (ITP), hepatitis C-related thrombocytopenia, and severe aplastic anemia.

Q2. How does Eltrombopag work?

A: It stimulates platelet production by binding to and activating the thrombopoietin receptor on bone marrow cells, leading to an increase in platelet count.

Q3. How should I take Rompag 25mg Tablet?

A: Take it on an empty stomach, either 1 hour before or 2 hours after meals. Avoid taking it with dairy or mineral supplements. Always follow your doctor’s instructions regarding dosage and timing.

Q4. Can I stop taking this medicine suddenly?

A: No, stopping the medicine suddenly can cause your platelet levels to drop drastically, increasing the risk of bleeding. Always consult your doctor before stopping the treatment.

Q5. How long does it take to work?

A: Some patients may notice an improvement in platelet counts within 1 to 2 weeks, but it can vary depending on the condition and response to treatment.