Sofovir 400mg Tablet

1. Product Introduction

Sofovir 400mg Tablet is a prescription antiviral medication containing Sofosbuvir (400mg) as the active ingredient. It is used primarily in the treatment of chronic Hepatitis C virus (HCV) infection in adults. Sofosbuvir belongs to a class of drugs called nucleotide polymerase inhibitors. It works by preventing the replication of the hepatitis C virus in the body, effectively lowering the viral load and helping the liver recover from infection.

Sofovir is not used alone. It is typically prescribed in combination with other antiviral agents such as ledipasvir, daclatasvir, ribavirin, or velpatasvir, depending on the genotype of the virus and the patient’s medical condition. The treatment duration generally ranges from 8 to 24 weeks, depending on the severity of the infection and response to therapy.

This medicine offers a significant advancement in hepatitis C treatment, with high cure rates and fewer side effects compared to older therapies such as interferon-based regimens.

2. Uses of Sofovir 400mg Tablet

Sofovir 400mg is used for the treatment of:

• Chronic Hepatitis C Virus (HCV) Infection
  It is effective against all six major genotypes of the HCV virus, often in combination with other medications.

• Compensated and Decompensated Liver Disease
  It can be used in patients with mild (compensated) or advanced (decompensated) liver damage.

• HCV with or without Cirrhosis
  Suitable for use in both cirrhotic and non-cirrhotic patients.

• Post-liver transplant HCV recurrence
  Used to manage hepatitis C in patients who have undergone liver transplantation.

3. Benefits of Sofovir 400mg Tablet

• High Cure Rates
  Sofovir has demonstrated cure rates (Sustained Virologic Response or SVR) of over 90% when used in combination therapy, meaning the virus becomes undetectable in the blood after completing the course.

• Well-Tolerated Therapy
  Compared to older interferon-based treatments, Sofovir offers a more comfortable experience with fewer severe side effects.

• Oral Administration
  Being an oral tablet, it is easy to use at home without the need for injections or hospital visits.

• Shorter Treatment Duration
  Sofovir-based regimens often require 12 to 24 weeks of treatment—significantly shorter than older therapies that lasted up to 48 weeks.

• Prevents Liver Damage Progression
  By eliminating the virus, it helps prevent serious complications such as liver cirrhosis, liver failure, and hepatocellular carcinoma (liver cancer).

• Improves Liver Function
  Clearing the virus gives the liver a chance to heal, improving overall liver function and patient well-being.

4. Side Effects

While Sofovir 400mg Tablet is generally well tolerated, some patients may experience mild to moderate side effects. These are usually manageable and disappear after a few days or weeks.

Common Side Effects:

• Fatigue or tiredness

• Headache

• Nausea

• Insomnia (difficulty sleeping)

• Diarrhea

Less Common but Serious Side Effects (Seek medical attention if any occur):

• Shortness of breath or irregular heartbeat

• Severe skin rash or allergic reaction

• Yellowing of skin or eyes (jaundice)

• Confusion or mood changes (especially in liver-compromised patients)

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