Akynzeo 300mg/0.5mg Capsule

1. Product Introduction

Akynzeo 300mg/0.5mg Capsule is a powerful antiemetic medication specially designed to prevent nausea and vomiting associated with chemotherapy treatments. It contains a fixed-dose combination of two active ingredients — Netupitant (300mg) and Palonosetron (0.5mg) — that work synergistically to provide long-lasting protection against both acute and delayed chemotherapy-induced nausea and vomiting (CINV).

Netupitant is a neurokinin-1 (NK1) receptor antagonist, and Palonosetron is a 5-HT3 receptor antagonist. Together, they block the signals in the brain that trigger nausea and vomiting. This capsule is taken orally, typically one hour before chemotherapy, and is effective for up to five days after treatment. Akynzeo simplifies antiemetic therapy by combining two highly effective agents into a single dose, reducing pill burden and improving patient compliance.

2. Uses of Akynzeo Capsule

Akynzeo 300mg/0.5mg Capsule is primarily used for the prevention of nausea and vomiting associated with cancer chemotherapy, including:

• Highly emetogenic chemotherapy (HEC) – such as cisplatin-based regimens.

• Moderately emetogenic chemotherapy (MEC) – including combinations like carboplatin and cyclophosphamide.

• Acute and delayed phases of chemotherapy-induced nausea and vomiting.

This medicine is part of a preventive regimen and is not used to treat nausea or vomiting once it has occurred. It is always administered before chemotherapy to block the emetic pathways activated by anti-cancer drugs.

3. Benefits of Akynzeo Capsule

• Dual Mechanism for Strong Protection:
  The combination of Netupitant and Palonosetron targets both the acute (within 24 hours) and delayed (after 24 hours) phases of CINV, offering comprehensive protection.

• Long-Lasting Effect:
  One single oral dose of Akynzeo provides up to 5 days of protection against nausea and vomiting, reducing the need for additional antiemetics.

• Improved Patient Comfort:
  By preventing nausea and vomiting, Akynzeo significantly improves the quality of life and comfort of patients undergoing chemotherapy.

• Simplifies Treatment Regimen:
  Unlike other antiemetics that require multiple doses, Akynzeo offers single-dose convenience, reducing the number of medications a patient must remember to take.

• Clinically Proven Efficacy:
  Akynzeo has been shown in clinical trials to be more effective than using a 5-HT3 antagonist alone, especially in preventing delayed nausea.

• Better Adherence:
  Its once-per-chemotherapy-cycle dosing ensures better adherence to antiemetic protocols, especially for outpatient chemotherapy treatments.

4. Side Effects

Akynzeo is generally well tolerated, but like all medicines, it may cause some side effects in certain individuals. Most side effects are mild and temporary.

Common Side Effects:

• Headache

• Constipation

• Fatigue or weakness

• Indigestion or heartburn

• Dizziness

Less Common Side Effects:

• Hiccups

• Abdominal pain

• Decreased appetite

Rare but Serious Side Effects (Seek medical attention immediately):

• Allergic reactions (rash, itching, swelling, difficulty breathing)

• Irregular heartbeat or chest pain

• Severe constipation or gastrointestinal blockage

If any of these side effects persist or worsen, inform your doctor immediately. Patients with liver problems should use this medicine under close medical supervision.

5. Frequently Asked Questions (FAQ)

Q1. What is Akynzeo used for?
A: Akynzeo is used to prevent nausea and vomiting caused by chemotherapy in cancer patients. It is particularly effective against both acute (within 24 hours) and delayed (up to 5 days) chemotherapy-induced nausea.

Q2. How should I take Akynzeo Capsule?
A: Take one capsule orally about one hour before starting chemotherapy, as directed by your doctor. It is a single-dose medicine per chemotherapy cycle.

Q3. Can I take Akynzeo on an empty stomach?
A: Yes, Akynzeo can be taken with or without food. However, follow your doctor’s instructions for best results.

Q4. Can I take Akynzeo with other antiemetics?
A: In some cases, your doctor may prescribe Akynzeo alongside dexamethasone (a corticosteroid) or other supportive care medicines, depending on your chemotherapy regimen.

Q5. Is Akynzeo safe for long-term use?
A: Akynzeo is typically used before each cycle of chemotherapy, not for continuous use. It is safe when taken as prescribed during chemotherapy treatment cycles.