Lenvatol 4mg Capsule

1. Product Introduction

Lenvatol 4mg Capsule is an anti-cancer medicine used in the treatment of certain types of advanced cancers. The active ingredient, Lenvatinib, is a multi-kinase inhibitor that blocks specific proteins (receptors for VEGFR, FGFR, PDGFR, RET, and KIT) involved in tumor growth, angiogenesis (formation of blood vessels that supply tumors), and cancer cell proliferation.

Lenvatol is typically prescribed for patients with advanced thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma (liver cancer) that cannot be surgically removed or has spread to other parts of the body. It works by starving the cancer cells of the nutrients and oxygen they need to grow.

Administered in capsule form, Lenvatol offers a convenient oral treatment option for patients undergoing targeted therapy. It should always be taken under the strict supervision of an oncologist.

2. Uses of Lenvatol 4mg Capsule

Lenvatol 4mg is prescribed for the treatment of the following cancers:

• Thyroid Cancer: Specifically for patients with differentiated thyroid carcinoma (DTC) that is radioiodine-refractory, meaning the cancer no longer responds to radioactive iodine treatment.

• Hepatocellular Carcinoma (HCC): For unresectable (inoperable) primary liver cancer.

• Renal Cell Carcinoma (RCC): In combination with other medications (like Everolimus), for treating advanced kidney cancer.

• Endometrial Cancer (off-label use): In combination with Pembrolizumab for patients with advanced endometrial cancer, especially in cases where other treatments have failed (as approved in some international guidelines).

3. Benefits of Lenvatol 4mg Capsule

• Targeted Therapy: Lenvatinib selectively inhibits cancer cell growth by blocking key signaling pathways responsible for tumor progression.

• Slows Disease Progression: It helps in controlling the growth of tumors and delays disease advancement in aggressive cancers.

• Effective in Radioiodine-Refractory Thyroid Cancer: A major option for patients who have failed standard radioactive iodine therapy.

• Oral Administration: Being an oral capsule, it avoids the need for intravenous infusions and can be taken at home, under supervision.

• Improved Survival in Advanced Cancers: Clinical trials have shown Lenvatinib to significantly prolong progression-free survival (PFS) and overall survival (OS) in advanced-stage cancers.

• Angiogenesis Inhibition: By cutting off the tumor’s blood supply, it indirectly reduces tumor size and viability.

4. Side Effects

While Lenvatol 4mg Capsule is highly effective, it may cause certain side effects, especially when used over a prolonged period. Not all patients experience them, and most can be managed with supportive treatment.

Common Side Effects:

• High blood pressure (hypertension)

• Fatigue and weakness

• Loss of appetite

• Weight loss

• Diarrhea

• Nausea and vomiting

• Abdominal pain

• Muscle or joint pain

• Swelling in hands, feet, or legs

Less Common but Serious Side Effects:

• Protein in urine (proteinuria)

• Blood clot formation

• Liver or kidney dysfunction

• Heart problems (such as QT prolongation or heart failure)

• Bleeding events

• Wound healing complications

• Severe diarrhea or dehydration

Precautions:

• Regular monitoring of blood pressure, liver function, and electrolyte levels is necessary.

• Not recommended during pregnancy or breastfeeding.

• Should be used cautiously in patients with heart conditions or kidney disease.

• Avoid alcohol and grapefruit juice while on Lenvatinib as it may interact with the drug.

5. Frequently Asked Questions (FAQ)

Q1. What is Lenvatol 4mg used for?
A: Lenvatol 4mg is used to treat advanced thyroid cancer, liver cancer (HCC), and kidney cancer (RCC), especially when surgery is not an option or other treatments have failed.

Q2. How does Lenvatinib work?
A: It works by blocking multiple enzymes (kinases) that promote the growth of cancer cells and the formation of blood vessels supplying the tumor.

Q3. How should I take Lenvatol 4mg Capsule?
A: Take it once daily with or without food, as prescribed by your doctor. Swallow the capsule whole with water—do not crush or chew.

Q4. Can I stop taking Lenvatol if I feel better?
A: No, you should not stop the medicine unless advised by your doctor. Discontinuing treatment can lead to disease progression.

Q5. What precautions should I take during treatment?
A: Monitor blood pressure regularly, stay hydrated, avoid alcohol, and inform your doctor about any side effects or other medications you’re taking.