Luprodex Depot 11.25mg Injection

1. Product Introduction

Luprodex Depot 11.25mg Injection is a long-acting hormone-based medication containing Leuprolide, a synthetic analogue of gonadotropin-releasing hormone (GnRH). It is used to regulate the production of sex hormones—mainly testosterone in men and estrogen in women—by acting on the pituitary gland. Leuprolide works by initially stimulating and then subsequently suppressing the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby reducing hormone levels.

This injection is administered as a depot formulation, which means it releases the drug slowly over a period of 3 months (approximately 12 weeks) after a single dose. It is commonly used to treat hormone-responsive conditions such as prostate cancer, endometriosis, uterine fibroids, and central precocious puberty.

Luprodex Depot 11.25mg should always be administered by a trained healthcare provider in a clinical setting.

2. Uses of This Medicine

Luprodex Depot 11.25mg Injection is prescribed for various medical conditions where hormone suppression is beneficial. Key indications include:

• Prostate Cancer (Advanced or Metastatic): Reduces testosterone levels, which helps in slowing down the growth of hormone-sensitive prostate cancer cells.

• Endometriosis: Lowers estrogen levels in women, thereby reducing pain and inflammation associated with endometrial tissue outside the uterus.

• Uterine Fibroids (Leiomyoma): Helps shrink fibroids and reduce heavy menstrual bleeding, especially when used prior to surgery.

• Breast Cancer (in premenopausal women): Used to suppress ovarian function in hormone receptor-positive breast cancers.

• Central Precocious Puberty (CPP): Treats early onset puberty in children by delaying physical development until a more appropriate age.

3. Benefits of This Medicine

Luprodex Depot 11.25mg Injection offers several clinical benefits, particularly for patients suffering from hormone-sensitive diseases:

• Long-Lasting Effect: One injection lasts for 3 months, reducing the need for frequent dosing and improving patient convenience and compliance.

• Effective Hormone Suppression: Helps in significantly lowering estrogen and testosterone levels, which slows disease progression in cancers and alleviates symptoms in gynecological disorders.

• Non-Surgical Management: Offers an alternative to surgical treatments for conditions like fibroids and endometriosis.

• Pre-Surgical Preparation: Shrinks fibroids and stabilizes the uterus before surgery, making procedures safer and more effective.

• Delays Early Puberty: For children with precocious puberty, it allows normal psychological and physical development by delaying premature hormonal changes.

• Improves Fertility Treatment Outcomes: Sometimes used in assisted reproduction to control hormonal levels and enhance IVF success rates.

4. Side Effects

Like all medications, Luprodex Depot 11.25mg may cause some side effects, which vary in intensity from person to person. Most are temporary and manageable under medical supervision.

Common Side Effects:

• Hot flashes

• Sweating

• Headache

• Fatigue

• Mood swings or depression

• Vaginal dryness or irregular bleeding in women

• Decreased libido (sex drive)

• Injection site reactions (pain, redness, swelling)

Less Common or Serious Side Effects:

• Bone thinning or osteoporosis with long-term use

• Breast tenderness or gynecomastia in men

• Weight gain

• Nausea

• Joint or muscle pain

• Temporary worsening of symptoms in prostate cancer patients (“tumor flare”)

• Elevated blood sugar or cholesterol levels

Precautions:

• Not suitable for use during pregnancy or breastfeeding.

• Bone density may need to be monitored during prolonged use.

• Hormone levels and treatment response should be regularly evaluated by your doctor.

5. Frequently Asked Questions (FAQ)

Q1. What is Luprodex Depot 11.25mg Injection used for?
Luprodex Depot 11.25mg is used for hormone-dependent conditions like prostate cancer, endometriosis, fibroids, early puberty, and certain types of breast cancer in women.

Q2. How is Luprodex 11.25mg administered?
It is given as a deep subcutaneous or intramuscular injection by a healthcare professional. The medication is designed to release slowly over a period of 12 weeks.

Q3. How long does it take to see results with Luprodex?
Most patients begin to experience effects within a few weeks. However, full benefits may take a little longer, depending on the condition being treated.

Q4. Can Luprodex cause menopause-like symptoms?
Yes. Because it reduces estrogen levels in women, it can cause symptoms like hot flashes, mood swings, and vaginal dryness, similar to menopause.

Q5. Is the effect of Luprodex permanent?
No. The hormone-suppressing effect is temporary and typically reversible after discontinuation. Normal hormonal function usually returns over time.