Mabtas 100mg Injection

1. Product Introduction

Mabtas 100mg Injection is a monoclonal antibody medicine that contains Rituximab, a powerful agent used primarily in the treatment of certain blood cancers and autoimmune diseases. Rituximab is designed to target and destroy a protein called CD20, which is found on the surface of B-cells, a type of white blood cell. This targeted action helps reduce abnormal B-cell growth, making it highly effective in various types of lymphoma, leukemia, and immune disorders.

Mabtas belongs to a class of medicines known as biologic therapies. It is typically given as an intravenous infusion under strict medical supervision in hospitals or specialty cancer centers. Mabtas is available as a biosimilar version of the original Rituximab (Rituxan or MabThera), offering similar efficacy and safety at a more affordable cost.

2. Uses of Mabtas 100mg Injection

Mabtas is used to treat several serious and chronic health conditions. Its primary indications include:

• Non-Hodgkin’s Lymphoma (NHL): Especially follicular and diffuse large B-cell lymphomas, either alone or with chemotherapy.

• Chronic Lymphocytic Leukemia (CLL): In combination with other cancer-fighting drugs.

• Rheumatoid Arthritis (RA): In adult patients who have not responded adequately to other disease-modifying antirheumatic drugs (DMARDs).

• Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA): Autoimmune diseases affecting blood vessels.

• Pemphigus Vulgaris: A rare autoimmune skin disease.

Mabtas can be used both as first-line treatment and in relapsed/refractory conditions depending on the type and severity of disease.

3. Benefits of Mabtas 100mg Injection

• Targeted Cancer Therapy: Rituximab specifically targets B-cells that express the CD20 protein, helping to destroy cancer cells while sparing healthy tissues.

• Effective in B-cell Blood Cancers: Shows high response rates in Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia.

• Useful in Autoimmune Diseases: Provides relief in diseases like rheumatoid arthritis and vasculitis by depleting B-cells responsible for autoimmune attacks.

• Improves Quality of Life: For many patients, Mabtas can help reduce symptoms, improve remission times, and extend survival.

• Can be Combined with Other Therapies: Works synergistically with chemotherapy agents, increasing their effectiveness.

• Biosimilar Advantage: Mabtas is a cost-effective alternative to original Rituximab formulations, making life-saving treatment more accessible.

4. Side Effects

While Mabtas is a powerful medicine with proven benefits, it can also cause side effects. Most of these are manageable with proper monitoring.

Common Side Effects:

• Infusion-related reactions (fever, chills, rash, headache)

• Fatigue

• Nausea and vomiting

• Muscle or joint pain

• Cough or sore throat

• Low blood cell counts (anemia, neutropenia)

• High blood pressure

Serious Side Effects (Less Common):

• Severe allergic reactions or anaphylaxis

• Infections (respiratory, urinary, or systemic)

• Reactivation of hepatitis B virus (if previously infected)

• Progressive multifocal leukoencephalopathy (PML) – a rare brain infection

• Heart-related problems in people with existing cardiac disease

• Tumor lysis syndrome (a potentially life-threatening condition due to rapid tumor breakdown)

Precautions:

• Regular monitoring of blood counts, liver function, and infection status is necessary.

• Patients must be screened for hepatitis B before starting therapy.

• Not recommended during pregnancy or breastfeeding unless specifically advised.

5. Frequently Asked Questions (FAQ)

Q1. What is Mabtas 100mg Injection used for?
A: Mabtas is used to treat certain types of blood cancers like Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia, as well as autoimmune diseases such as rheumatoid arthritis and pemphigus vulgaris.

Q2. How does Rituximab work?
A: Rituximab targets CD20 proteins found on B-cells and destroys them. In cancer, this helps eliminate abnormal cells. In autoimmune diseases, it reduces the immune system’s attack on the body.

Q3. How is Mabtas administered?
A: Mabtas is given as an intravenous infusion in a hospital setting. The first infusion is given slowly to monitor for side effects. Later doses may be given more quickly if tolerated well.

Q4. Can Mabtas cause infections?
A: Yes, because it reduces B-cell counts, your immune system becomes weaker, making you more prone to infections. Proper precautions and medical monitoring are advised.

Q5. How long does Mabtas take to show results?
A: It depends on the condition being treated. In cancers, responses may be seen after a few cycles. In autoimmune diseases, it may take several weeks to months for full benefits.