Paleno 75mg Capsule

1. Product Introduction

Paleno 75mg Capsule contains the active ingredient Palbociclib, a targeted therapy medication classified as a CDK4/6 inhibitor. It is primarily used to treat certain types of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. This form of breast cancer is commonly seen in postmenopausal women and often relies on hormones to grow and spread.

Palbociclib works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6)—enzymes that are responsible for regulating the cell cycle. By blocking these enzymes, the medicine halts the growth of cancer cells and prevents them from dividing further. Paleno is generally used in combination with hormonal therapies such as letrozole or fulvestrant for maximum effectiveness.

This medicine is an oral chemotherapy drug and is typically taken once a day in a 21-days-on, 7-days-off cycle. Its use must be closely supervised by an oncologist due to its potent activity and potential side effects.

2. Uses of Paleno 75mg Capsule

Paleno 75mg is prescribed for the treatment of:

• HR+/HER2- Advanced or Metastatic Breast Cancer
  In patients who are either postmenopausal women or men with this specific subtype of breast cancer, especially when the cancer has spread to other parts of the body.

• Combination with Letrozole (first-line treatment)
  For patients with no prior endocrine therapy for metastatic disease.

• Combination with Fulvestrant
  For patients who have disease progression following endocrine therapy.

3. Benefits of Paleno 75mg Capsule

• Targeted Therapy with Fewer Side Effects Than Chemotherapy
  As a CDK4/6 inhibitor, Paleno specifically targets cancer cell growth, often sparing healthy cells, thus offering a more focused treatment option than traditional chemotherapy.

• Prolongs Progression-Free Survival
  Clinical studies have shown that Palbociclib significantly delays disease progression when used in combination with hormone therapy.

• Non-Invasive Oral Treatment
  Being an oral capsule, it provides patients with the convenience of at-home therapy, reducing the need for hospital visits for infusions.

• Delays Need for Traditional Chemotherapy
  Its efficacy can often delay the use of more aggressive treatments like cytotoxic chemotherapy.

• Well Tolerated in Combination Regimens
  When used as directed with hormone therapy, it has a manageable side effect profile that allows long-term use in eligible patients.

4. Side Effects

Like all anticancer medications, Paleno 75mg may cause side effects. These vary from person to person, and not all patients will experience them.

Common Side Effects:

• Neutropenia (low white blood cell count) – Most common side effect, which increases infection risk.

• Fatigue

• Nausea

• Diarrhea or constipation

• Hair thinning or mild hair loss

• Mouth sores (stomatitis)

• Decreased appetite

Less Common Side Effects:

• Anemia

• Headache

• Skin rash

• Vomiting

• Joint or muscle pain

Serious Side Effects (Seek immediate medical help):

• Signs of infection (fever, chills, sore throat)

• Breathing difficulties or cough

• Severe allergic reaction (rash, itching, swelling, difficulty breathing)

• Liver dysfunction (dark urine, yellowing of eyes or skin)

Routine blood tests are essential to monitor your white blood cell count, liver function, and overall treatment progress. Your doctor may adjust the dosage based on your body’s response.

5. Frequently Asked Questions (FAQ)

Q1. What is Paleno 75mg used for?
A: Paleno 75mg Capsule is used to treat HR+/HER2- metastatic or advanced breast cancer, typically in combination with hormone therapies such as letrozole or fulvestrant.

Q2. How should I take Paleno 75mg?
A: Take one capsule orally once a day with food, usually on a 21-day treatment followed by a 7-day break. Swallow the capsule whole—do not crush or chew it.

Q3. Can men use Paleno for breast cancer?
A: Yes, Palbociclib is also used in men with HR+/HER2- metastatic breast cancer, particularly in combination with hormone therapies.

Q4. What should I do if I miss a dose?
A: Skip the missed dose and take the next dose at the scheduled time. Do not double up to make up for the missed dose. Consult your doctor if you miss multiple doses.

Q5. Are there any dietary restrictions while using Paleno?
A: Avoid grapefruit and grapefruit juice, as they can increase the levels of Palbociclib in the blood, leading to enhanced side effects.