Regonat 40mg Tablet

1. Product Introduction

Regonat 40mg Tablet is an advanced oral anticancer medication containing Regorafenib, a multi-kinase inhibitor. It is used in the treatment of certain types of advanced cancers, particularly in cases where other treatment options have failed or stopped working. Regorafenib works by blocking several enzymes (kinases) that promote the growth of cancer cells and blood vessels that feed tumors, thereby slowing disease progression.

Manufactured by Natco Pharma, Regonat is known for its quality and cost-effectiveness, making it a valuable option in cancer care. It is usually prescribed as part of a comprehensive treatment plan, often after the failure of conventional chemotherapies or targeted agents.

The tablet is taken orally, usually once a day for a cycle of 3 weeks on and 1 week off, under strict medical supervision. Regonat helps manage cancers such as colorectal cancer, gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (liver cancer).

2. Uses of This Medicine

Regonat 40mg Tablet is primarily indicated for the treatment of the following cancers:

• Metastatic Colorectal Cancer (mCRC):
  In patients who have been previously treated with standard therapies (fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, anti-VEGF therapy, and anti-EGFR therapy).

• Gastrointestinal Stromal Tumor (GIST):
  For patients who have previously been treated with imatinib and sunitinib but have shown resistance or disease progression.

• Hepatocellular Carcinoma (HCC):
  Used in patients who have been previously treated with sorafenib, another tyrosine kinase inhibitor.

These indications are based on clinical studies where Regorafenib has shown significant improvement in progression-free survival in patients who have exhausted other treatment options.

3. Benefits of This Medicine

Regonat offers significant benefits for patients suffering from hard-to-treat and advanced-stage cancers:

• Multi-Kinase Inhibition:
  Regorafenib blocks multiple kinases involved in tumor growth, blood vessel formation (angiogenesis), and cancer cell proliferation, making it highly effective in slowing cancer progression.

• Delays Disease Progression:
  In clinical trials, Regorafenib has demonstrated an ability to extend progression-free survival, especially in metastatic colorectal cancer and advanced GIST.

• Oral Convenience:
  Being an oral tablet, Regonat allows cancer patients to manage their treatment at home without the need for frequent hospital visits for infusions.

• Second- and Third-Line Therapy:
  Regonat is an important treatment option for patients who have not responded to first-line or second-line therapies, giving them a new chance at disease control.

• Improves Quality of Life:
  While not curative, Regorafenib may improve symptoms, provide pain relief, and enhance quality of life by stabilizing disease.

4. Side Effects

Like all cancer medications, Regonat 40mg Tablet can cause side effects. The intensity and frequency of these side effects may vary from person to person.

Common Side Effects:

• Fatigue

• Diarrhea

• Loss of appetite

• Weight loss

• High blood pressure (hypertension)

• Hand-foot skin reaction (palmar-plantar erythrodysesthesia)

• Voice changes (hoarseness)

• Nausea and vomiting

• Increased liver enzymes (ALT/AST)

Serious Side Effects:

• Severe liver damage

• Gastrointestinal perforation (tear in the gut)

• Cardiac events like chest pain or heart attack (rare)

• Severe skin reactions (rash, peeling)

Precautions:

• Liver function tests and blood pressure monitoring are recommended regularly during treatment.

• Treatment may need to be interrupted or dose-adjusted in case of severe side effects.

• Hydration, nutrition, and supportive care are crucial while on Regorafenib.

Patients should immediately report any unusual symptoms such as yellowing of the skin or eyes, bleeding, severe abdominal pain, or chest discomfort to their doctor.

5. Frequently Asked Questions (FAQ)

Q1. What is Regonat 40mg Tablet used for?
A: Regonat is used to treat metastatic colorectal cancer, advanced gastrointestinal stromal tumors, and liver cancer (hepatocellular carcinoma) when other treatments have failed.

Q2. How should I take Regonat 40mg Tablet?
A: Regonat is usually taken once daily for 21 days followed by 7 days off, in a 28-day cycle. Always take it with a low-fat meal and as directed by your doctor.

Q3. Can Regonat cure cancer?
A: Regonat is not a cure but a treatment to control the growth of advanced cancer, prolong survival, and improve quality of life.

Q4. What should I do if I miss a dose?
A: If you miss a dose, skip it and take your next dose at the regular time. Do not double the dose. Inform your doctor if multiple doses are missed.

Q5. Is it safe to drive while taking Regonat?
A: Regonat may cause fatigue or dizziness in some patients. Avoid driving or operating machinery until you know how the medicine affects you.