Trombopag 25mg Tablet

1. Product Introduction

Trombopag 25mg Tablet contains Eltrombopag, a medication that belongs to a class of drugs known as thrombopoietin receptor agonists. It is used to stimulate the production of platelets in the bone marrow. Platelets are essential blood components that help prevent and stop bleeding by forming clots.

Eltrombopag works by activating the thrombopoietin receptor, a protein found on the surface of bone marrow cells, which then signals the body to increase the production of platelets. This action is especially important for people whose platelet counts are dangerously low due to certain medical conditions or treatments.

Trombopag is available in oral tablet form and is typically used under close medical supervision. It is not a cure but helps manage conditions related to low platelet counts and reduces the need for platelet transfusions.

2. Uses of This Medicine

Trombopag 25mg Tablet is prescribed for several conditions involving low platelet counts (thrombocytopenia), including:

• Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP):
  Used in adults and children over 1 year who have not responded adequately to other treatments such as corticosteroids, immunoglobulins, or splenectomy.

• Severe Aplastic Anemia (SAA):
  Used when the body stops producing enough new blood cells. Trombopag helps stimulate platelet production in combination with immunosuppressive therapy.

• Thrombocytopenia in Hepatitis C Virus (HCV) Infection:
  Used to increase platelet counts in patients undergoing antiviral treatment for HCV, allowing continuation or initiation of interferon-based therapy.

• Other Off-label Uses:
  In some cases, it may be prescribed in chemotherapy-induced thrombocytopenia or other blood disorders based on a specialist’s discretion.

3. Benefits of This Medicine

• Increases Platelet Production:
  The main benefit of Trombopag is its ability to increase the platelet count in patients suffering from low platelet-related disorders, thereby reducing the risk of bleeding.

• Reduces the Need for Platelet Transfusions:
  For patients with chronic conditions or those undergoing antiviral or immunosuppressive therapy, it significantly reduces dependency on frequent transfusions.

• Improves Treatment Continuation:
  In patients receiving antiviral therapy for Hepatitis C or undergoing chemotherapy, Trombopag allows uninterrupted treatment by correcting low platelet counts.

• Non-invasive Treatment:
  As an oral tablet, it provides a convenient alternative to injectable therapies or transfusions.

• Better Quality of Life:
  By maintaining a safer platelet level, patients can engage in more physical activities and experience fewer symptoms like bruising, fatigue, and bleeding gums.

4. Side Effects

While Trombopag is generally well-tolerated, like any medication, it may cause side effects in some patients.

Common Side Effects:

• Nausea

• Diarrhea

• Fatigue

• Headache

• Upper respiratory tract infection

• Back pain

• Increased liver enzymes (transaminases)

Serious Side Effects (Less Common):

• Liver toxicity: Elevated liver enzymes and bilirubin levels. Regular liver function monitoring is essential.

• Thrombotic events: Risk of blood clots if platelet count increases too much.

• Cataracts: Especially with long-term use.

• Bone marrow fibrosis: Rare, but a potential risk with prolonged therapy.

Precautions:

• Regular blood tests are required to monitor platelet counts and liver function.

• Should not be used to normalize platelet counts completely—only to maintain safe levels.

• Not recommended for use during pregnancy or breastfeeding unless absolutely necessary.

• Patients should avoid antacids and calcium-rich foods within 4 hours of taking the tablet as it may affect absorption.

Always take this medicine under the supervision of a healthcare provider.

5. Frequently Asked Questions (FAQ)

Q1. What is Trombopag 25mg used for?
A: Trombopag is used to treat conditions where the body has low platelet counts, such as chronic ITP, severe aplastic anemia, and thrombocytopenia due to hepatitis C treatment.

Q2. How does Eltrombopag work?
A: It works by activating thrombopoietin receptors in the bone marrow, which then stimulate the production of platelets in the blood.

Q3. How long does it take for Trombopag to increase platelet counts?
A: Some patients may see a rise in platelet count within 1–2 weeks, but full response can take up to 4 weeks or more, depending on the condition and individual response.

Q4. Can Trombopag be taken with food?
A: Yes, but it should not be taken with dairy products, calcium-fortified juices, or antacids, as these may reduce the drug’s effectiveness.

Q5. What if I miss a dose?
A: Take the missed dose as soon as you remember. If it is close to the next dose, skip the missed one. Do not double dose.